Unified Separation’s Bonnasil silica media is composed of high purity spherical silica gel with a uniform pore distribution and proprietary asymmetric bonding technology designed to support efficient and reliable separations across various applications. The Bonnasil product line includes three types: Bonnasil-BS, Bonnasil-HS, and Bonnasil-CH. Each type is available in a range of particle sizes, pore sizes, and bonded phases, tailored to diverse separation requirements from bench-scale testing to large-scale production, ensuring a smooth and efficient purification process.
| Small Molecules | Polypeptides | GLP-1 | Small Nucleic Acid Drugs | Synthetic | Natural Products | |
|---|---|---|---|---|---|---|
| Bonnasil-HS | ✅ | ✅ | ✅ | ✅ | ✅ | |
| Bonnasil-BS | ✅ | ✅ | ✅ | ✅ | ✅ | ✅ |
| Bonnasil-CH | ✅ | ✅ | ✅ | ✅ |
Bonnasil-HS is a high-end chromatographic packing material produced through the sol-gel process using an ultra-high-purity silica source. Bonnasil-HS offers excellent control over particle size and pore size distribution, resulting in a larger effective surface area, reduced tailing, higher loading capacity, improved stability under high pH conditions, and greater mechanical strength. It is particularly suitable for the purification of peptide products, especially insulin, GLP-1, and their analogs.
The Bonnasil-CH series is a hybrid surface-treated alkali-resistant silica gel capable of withstanding high pH environments. It allows using a broader range of mobile phases, making it suitable for purifying alkaline compounds and fermentation products.
Bonnasil-BS is a high-performance line of chromatographic packing materials made from high-purity silica. It is designed for a wide range of small-molecule purifications and offers a versatile selection of particle sizes, pore sizes, and bonding phases, making it suitable for various purification needs. Bonnasil-BS delivers exceptional and balanced separation efficiency, loading capacity, recovery rate, and mechanical durability in both normal-phase and reversed-phase applications.